| Actor | Character | Seasons |
| Adawale Akinnuoye-Agbaje | |
| Naveen Andrews | |
| Nestor Carbonell | |
| Henry Ian Cusick | |
| Jeremy Davies | |
| Emilie de Ravin | |
| Michael Emerson | |
| Jeff Fahey | |
| Matthew Fox | |
| Jorge Garcia | |
| Maggie Grace | |
| Josh Holloway | |
| Malcolm David Kelley | |
| Daniel Dae Kim | |
| | Actor | Character | Seasons |
| Yunjin Kim | |
| Ken Leung | |
| Evangeline Lilly | |
| Rebecca Mader | |
| Elizabeth Mitchell | |
| Dominic Monaghan | |
| Terry O'Quinn | |
| Harold Perrineau | |
| Zuleikha Robinson | |
| Michelle Rodriguez | |
| Kiele Sanchez | |
| Rodrigo Santoro | |
| Ian Somerhalder | |
| Cynthia Watros | |
| L. Scott Caldwell (1-6) | |
| Sam Anderson (2-6) | |
| M.C. Gainey (1-4) | |
| Mira Furlan and Melissa Farman (1-6) | |
| Tania Raymonde (2-6) | |
| John Terry (1-6) | |
| Alan Dale (2-6) | |
| Kimberly Joseph (1-3, 6) | |
| Francois Chau (2-6) | |
| Sonya Walger (2-6) | |
| William Mapother (1-3, 5-6) | |
| Marsha Thomason (3-5) | |
| Christian Bowman (1-4) | |
| Dustin Watchman (1) | |
| Fredric Lehne (1-3, 6) | |
| Kevin Durand (4, 6) | |
| William Blanchette and other babies (1-5) | |
| Patrick Fischler (5) | |
| Blake Bashoff (3-4) | |
| Andrew Divoff (3, 6) | |
| Michael Bowen (2-3) | |
| Doug Hutchison (3-5) | |
| Daniel Roebuck (1, 3, 6) | |
| Anthony Azizi (4, 6) | |
| Jon Gries (3, 5-6) | |
| Andrea Gabriel (1-6) | |
| Eric Lange (5) | |
| Ariston Green (3) | |
| Fionnula Flanagan and Alice Evans (3, 5-6) | |
| Kevin Tighe (1-3) | |
| Beth Broderick (1-4) | |
| Julie Bowen (1-3) | |
| Lillian Hurst (1-5) | |
| Brad William Henke (5-6) | |
| Billy Ray Gallion (1-4, 6) | |
| Mark Pellegrino (5-6) | |
| Mickey Graue (2-3, 6) | |
| Kiersten Havelock (2-3, 6) | |
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