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| Only US President to hold a pHd | |
| Only mammal that can fly | |
| Only US state capital to border another nation | |
| Only Central American nation without an Atlantic coast | |
| Only current Supreme Court Justice without an Ivy League degree | |
| Only private Big Ten school | |
| Only animated film to receive a Best Picture nomination | |
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| Only Olympian to win 8 gold medals in one Olympic Games | |
| Only state with a unicameral legislature | |
| Only person to be a governor of two different US states | |
| Only person to win back-to-back Heisman trophies | |
| Only astronaut to fly in NASA's first three programs (Mercury, Gemini, Apollo) | |
| Only female to serve as US Attorney General | |
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