| Hint | Answer | What's First? |
| 2nd best selling album of all time | |
| 2nd most World Series championships | |
| 2nd most abundant element in the Earth's crust | |
| 2nd city to by destroyed by nuclear warfare | |
| 2nd best selling book of all time | |
| 2nd smallest US state | |
| 2nd most consecutive MLB games played | |
| 2nd Pope | |
| 2nd most common world religion | |
| 2nd largest planet | |
| 2nd largest bone in the human body | |
| 2nd man on the moon | |
| 2nd to last book of the Bible | |
| 2nd largest sea | |
| 2nd tallest building in the world | |
| 2nd most number of total speakers, but not native speakers | |