DNA Replication, Repair, & Recombination

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Can you name the relevant terms of DNA replication, repair, & recombination?

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ClueAnswer
Nonhomologous end joining as a form of double-stranded break repair is mediated by ____ proteins, but ultimately leads to the accrual of permanent DNA deletions called _____.
These proteins are the first to bind to the bacterial chromosome in replication, and do so upstream of the DUE.
This is the most common nitrogenous base to dimerize in response to UV light exposure.
This is formed during recombination of sister chromatids; its resolution determines the ultimate resulting sequences.
This type of recombination is limited to particular areas of the chromosome.
This form of double-stranded break repair depends on recombination with sister chromatids for more effective repair, and is thus limited to the S and G2 phases of the cell cycle.
Associated with each core polymerase domain is a ______, which holds the DNA in place.
This process proceeds DNA replication at eukaryotic origins.
The number of nucleotides processed by DNA polymerase before its dissociation from DNA is referred to as the polymerase's:
The DUE is rich in the nitrogenous bases ________ and _______, enabling its rapid denaturation.
This is the most common cause of point deletions, due to hydrolytic attack between the nitrogenous base and sugar.
What two molecules can be DIRECTLY synthesized using DNA as a template?
This protein initiates recombination in meiosis.
The exonuclease activity of DNApol II proceeds in the _'-to-_' direction.
Just type in 'heteroduplex'. I'm all quizzed out.
The origin of replication for the bacterial chromosome is also known as:
The energy required for elongation in DNA synthesis is provided by the release of _________ from nucleotides.
The enyzme _________ uses an internal RNA template to extend the ends of chromosomes as a safeguard against degradation, leaving a _' overhang that is tucked into the molecule.
ClueAnswer
Because DNA polymerase can only polymerize existing nucleic acids, it requires an RNA _____ to begin elongation.
The protein complex that assembles at eukaryotic origins of replication:
_______ excision repair depends on removing an entire segment of DNA containing the defect, such as dimerized bases.
True or false: while there are multiple origins of replication in the eukaryotic genome, there is still only one per chromosome.
______ excision repair is employed when a mismatched base must be removed, followed by the rest of the nucleotide.
This segment of DNA at the origin of replication is where the strands first denature in replication.
These proteins continually bind to isolated DNA strands during replication, in order to stabilize and protect them.
These 'chunks' of DNA, produced during DNA elongation, are the only way to synthesize off the lagging strand, due to the unidirectionality of DNA polymerase.
DNA replication is semiconservative, meaning that each daughter molecule has ___ original strand and ___ new strand.
These proteins are present ONLY during S phase, due to the cell cycle's regulation, and are essential for loading helicase onto DNA.
Immediately following DNA replication in the bacterium, the daughter chromosomes are catenated. What TYPE of topoisomerase is required to separate them?
Replication termination is signaled by ___ proteins binding to ___ sequences, causing the arrest of replication forks.
True or false: there is a biological advantage to limited mutation.
This enzyme is coupled to polymerase, and unwinds the DNA at the replication fork.
Another form of DNA damage due to hydrolytic attack, where cytosine is converted to uracil.
The helicase involved in DNA replication in eukaryotes is also known as this.
This enzyme undoes coils formed upstream of the replication fork due to supercoiling.

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