MNE Metabolic Pathway Questions

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Can you name the Metabolic Components?

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Citrate synthase, isocitrate dehydrogenase, and alpha ketoglutarate dehydrogenase all have in common that they are ACTIVATED (up-regulated) by ____
Which cofactor of the pyruvate dehydrogenase complex is derived from pantothenic acid?
What is the alpha ketoacid of aspartate?
Where is succinate dehydrogenase located in the cell?
What is the name of the three carbon compound that is left over at the end of beta oxidation of an odd-numbered FA chain?
Nucleotides, coenzymes, DNA, and RNA are all derived from which important derivative of the pentose phosphate pathway?
In the Metabolic Stress & Starvation module of self-directed learning videos, what is the name of the child who obtained his father's gun and got capped by his friend with it?
Low concentrations of oxaloacetate drive the reaction of this enzyme in the mitochondria, despite its unfavorable (positive) free energy change.
NADH can be generated in the brain from the breakdown of ketones using which enzyme?
Mg2+ is a necessary cofactor for PFK-1, phosphoglycerate kinase, and which other enzyme?
Major up-regulators of the enzyme in the first committed step of glycolysis are ADP, AMP, and ____
FA's are transported in aggregated compounds known as what?
The malate transporter is an antiporter that moves malate along with which other compound?
Each of the following is a regulator of PFK-1 EXCEPT: citrate, succinate, AMP, ATP.
Which enzyme of the TCA cycle can use either NADP+ or NAD+ to carry out its catalysis, depending on the particular isoform?
Which cofactor of the pyruvate dehydrogenase complex is NOT dervied from a B vitamin?
Which enzyme is responsible for catalyzing the highly endergonic reaction of cleaving fructose-1,6-bisphosphate?
Pyruvate can be used to generate acetyl-CoA, oxaloacetate, and which other TCA intermediate?
Which type of fuel can only provide a maximum of 30% of the brain's energy demands?
Beta-hydroxybutyrate is one ketone body that is able to be used for energy in peripheral tissues. What is the other?
Which enzymatic portion of the pyruvate dehydrogenase complex carries out an irreversible step?
Acetyl-CoA is released from beta-ketoacyl-CoA by which enzyme of beta oxidation?
Oxygen radicals are cleared by which compound that is regenerated by a product of the pentose phosphate pathway?
What is another name for the 'uncoupling protein' present in brown fat?
Which electron-carrier cofactor of the pyruvate dehydrogenase complex is riboflavin-based?
HintAnswer
The enzyme PFK1, which carries out the first committed step of glycolysis, is inhibited by which TCA intermediate?
Which enzyme is responsible for the reaction that makes glucose unable to leave the cell?
Acetyl-CoA promotes the phosphorylation and subsequent inhibition of the E1 domain of the pyruvate dehyrdogenase complex. Which other compound promotes this phosphorylation?
To prevent the F0F1 ATPase/ATP synthase enzyme from operating in the reverse direction during ischemia (lack of adequate oxygenation), this enzyme binds to the complex.
This symporter utilizes the proton gradient to bring in a proton along with an inorganic phosphate molecule that will LATER be used to make ATP.
Beta oxidation can be halted by inhibiting CAT1 (carnitine acyltransferase 1) with which intermediate of FA synthesis?
Which enzyme phosphorylates perilipin and hormone-sensitive lipase to allow for the relase of TAG's (triacylglycerols) into free FA's?
What is the oxidized form of the cofactor of glycerol-3-phosphate?
Pyruvate is the alpha ketoacid of which amino acid?
How many total protons are pumped into the intermembrane space of the mitochondria when electrons are input into the ETC in the form of succinate
Cyanide poisoning interferes with the normal functioning of which complex of the ETC?
Beta oxidation of palmitate (16 carbon FA) yields how many acetyl-CoA molecules?
ATP contains two high energy _______ bonds.
The beta oxidation of odd-numbered FA chains will lead to which TCA intermediate?
Aspartate enters the mitochondrial matrix through an antiporter that exports which compound?
Which cation activates enzymes in the TCA cycle?
In the heart, liver, and kidney, we use a slow shuttle system to replenish NAD+. What is its name?
Oxaloacetate is reduced to which compound before being imported inot the mitochondrial matrix?
Where in the cell is the pyruvate dehydrogenase complex located?
Which compound aids in the digestion of triacylglycerols (TAG's)?
Ketogenesis starts with the reversal of the last step of which metabolic process?
What is the alpha ketoacid of glutamate?
The reason the liver cannot utilize ketone bodies for energy is that it lacks this enzyme.
What thiamine deficiency disease is typically seen in anorexic patients?
How many protons are required to form 1 ATP using F0F1 ATP synthase?

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