MNE Metabolic Pathway Questions

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Can you name the Metabolic Components?

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What is the alpha ketoacid of aspartate?
Which enzyme of the TCA cycle can use either NADP+ or NAD+ to carry out its catalysis, depending on the particular isoform?
What is the alpha ketoacid of glutamate?
This symporter utilizes the proton gradient to bring in a proton along with an inorganic phosphate molecule that will LATER be used to make ATP.
Where is succinate dehydrogenase located in the cell?
How many total protons are pumped into the intermembrane space of the mitochondria when electrons are input into the ETC in the form of succinate
Aspartate enters the mitochondrial matrix through an antiporter that exports which compound?
Oxygen radicals are cleared by which compound that is regenerated by a product of the pentose phosphate pathway?
What is another name for the 'uncoupling protein' present in brown fat?
Where in the cell is the pyruvate dehydrogenase complex located?
The malate transporter is an antiporter that moves malate along with which other compound?
Major up-regulators of the enzyme in the first committed step of glycolysis are ADP, AMP, and ____
Nucleotides, coenzymes, DNA, and RNA are all derived from which important derivative of the pentose phosphate pathway?
To prevent the F0F1 ATPase/ATP synthase enzyme from operating in the reverse direction during ischemia (lack of adequate oxygenation), this enzyme binds to the complex.
Beta-hydroxybutyrate is one ketone body that is able to be used for energy in peripheral tissues. What is the other?
What is the oxidized form of the cofactor of glycerol-3-phosphate?
Which cation activates enzymes in the TCA cycle?
Mg2+ is a necessary cofactor for PFK-1, phosphoglycerate kinase, and which other enzyme?
In the heart, liver, and kidney, we use a slow shuttle system to replenish NAD+. What is its name?
Low concentrations of oxaloacetate drive the reaction of this enzyme in the mitochondria, despite its unfavorable (positive) free energy change.
NADH can be generated in the brain from the breakdown of ketones using which enzyme?
The reason the liver cannot utilize ketone bodies for energy is that it lacks this enzyme.
Pyruvate can be used to generate acetyl-CoA, oxaloacetate, and which other TCA intermediate?
Which electron-carrier cofactor of the pyruvate dehydrogenase complex is riboflavin-based?
Beta oxidation of palmitate (16 carbon FA) yields how many acetyl-CoA molecules?
HintAnswer
The beta oxidation of odd-numbered FA chains will lead to which TCA intermediate?
FA's are transported in aggregated compounds known as what?
How many protons are required to form 1 ATP using F0F1 ATP synthase?
Which type of fuel can only provide a maximum of 30% of the brain's energy demands?
Each of the following is a regulator of PFK-1 EXCEPT: citrate, succinate, AMP, ATP.
Acetyl-CoA is released from beta-ketoacyl-CoA by which enzyme of beta oxidation?
What thiamine deficiency disease is typically seen in anorexic patients?
Which cofactor of the pyruvate dehydrogenase complex is NOT dervied from a B vitamin?
Beta oxidation can be halted by inhibiting CAT1 (carnitine acyltransferase 1) with which intermediate of FA synthesis?
Which enzyme phosphorylates perilipin and hormone-sensitive lipase to allow for the relase of TAG's (triacylglycerols) into free FA's?
Which enzymatic portion of the pyruvate dehydrogenase complex carries out an irreversible step?
ATP contains two high energy _______ bonds.
Which enzyme is responsible for catalyzing the highly endergonic reaction of cleaving fructose-1,6-bisphosphate?
What is the name of the three carbon compound that is left over at the end of beta oxidation of an odd-numbered FA chain?
Which compound aids in the digestion of triacylglycerols (TAG's)?
The enzyme PFK1, which carries out the first committed step of glycolysis, is inhibited by which TCA intermediate?
Citrate synthase, isocitrate dehydrogenase, and alpha ketoglutarate dehydrogenase all have in common that they are ACTIVATED (up-regulated) by ____
Oxaloacetate is reduced to which compound before being imported inot the mitochondrial matrix?
Which enzyme is responsible for the reaction that makes glucose unable to leave the cell?
Pyruvate is the alpha ketoacid of which amino acid?
In the Metabolic Stress & Starvation module of self-directed learning videos, what is the name of the child who obtained his father's gun and got capped by his friend with it?
Acetyl-CoA promotes the phosphorylation and subsequent inhibition of the E1 domain of the pyruvate dehyrdogenase complex. Which other compound promotes this phosphorylation?
Ketogenesis starts with the reversal of the last step of which metabolic process?
Cyanide poisoning interferes with the normal functioning of which complex of the ETC?
Which cofactor of the pyruvate dehydrogenase complex is derived from pantothenic acid?

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