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Environmental
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Environmental Agents Stats
Can you name the Environmental Agents?
By
EffDevBio
15m
42 Questions
3 Plays
3 Plays
3 Plays
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Score
0/42
Timer
15:00
0
Plays Today
Hint
Answer
% Correct
True or false: we know the dose threshold for almost all teratogens?
False
100%
True or false: There is no direct connection between fetus and mother
true
100%
used as anti-
morning sickness drug, children born w/
flipper limbs
thalidomide
66.7%
analogue of vitamin A
retinoic acid
66.7%
this is a xenoestrogen
BPA
66.7%
teratogens may demonstrate a _
_
_
_
_
relationship
dose-effect
33.3%
affects susceptibility to damage to certain organs/
systems and by some agents
developmental time
33.3%
_
_
_
_
_
molecules cross the placenta more easily
small
33.3%
the maternal-
fetal interface is the
placenta
33.3%
carries well-
oxygenated blood to the embryo/
vitellous area
umbilical vein
33.3%
return embryonic blood to placenta
umbilical arteries
33.3%
contain embryonic blood vessels
chorionic villi
33.3%
bathes chorionic villi
maternal blood
33.3%
inhibits cholesterol synthesis
jervine
33.3%
blocks Shh function
cyclopamine
33.3%
causes cyclopia
Veratrum Californicum
33.3%
The cell surface protein that holds tissues together
L1
33.3%
3rd most prevalent form of mental retardation
Fetal Alcohol Syndrome
33.3%
ethanol alters _
_
_
_
migration
neural crest
33.3%
ethanol also causes apoptosis of _
_
_
_
_
through generation of _
_
_
_
_
neurons, ROS
33.3%
ethanol blocks the adhesive function of this protein
L1
33.3%
Hint
Answer
% Correct
RA works by altering _
_
_
_
gene expression and results in altered _
_
_
_
_
_
_
patterning
Hox, anterior-posterior
33.3%
RA makes _
_
_
_
stop both migration and proliferation
cranial neural crest
33.3%
exogenous chmiecals that interfere with the function of hormones, special class of teatogens
endocrine disruptors
33.3%
suspected endocrine disruptors are mainly these 2 things
pesticides, plasticizers
33.3%
synthetic estrogen linked to vaginal cancer and defects in offspring
diethylstilbestrol
33.3%
these hormones regulate the 5' Hoxa cluster
estrogen, progesterone
33.3%
wnt5a mutant female reproductive tracts lack _
_
_
_
structures
posterior
33.3%
required for correct epithelial organization, radial growth, patterning if adjacent mesenchymal cells, organization of smooth muscle layers
Wnt7a
33.3%
positively regulates Wnt7a expression
Wnt5a
33.3%
DES works by binding to the _
_
_
_
_
_
and downregulating _
_
_
_
estrogen receptor, Wnt7a
33.3%
DES represses levels of these 2 genes
Hoxa10, Hoxa11
33.3%
BPA works by competing with _
_
_
_
_
for _
_
_
_
_
in MCF7 breast cancer cells
estradiol, estrogen receptors
33.3%
this is a stabilizer in polystyrene plastics that alters reproductive physiology, disrupts sperm function and count
n-nonylphenol
33.3%
this is a pesticide and anti-
androgenic endocrine disruptor
vinclozolin
33.3%
vinclozolin works by targeting _
_
_
_
to nucleus
androgen receptor
33.3%
vinclozolin has an _
_
_
_
_
/
_
_
_
_
_
_
dual function with _
_
_
_
agonist, antagonist, DHT
33.3%
33.3%
teratogens act with
specficity
0%
factors influencing the rate and extent of placental transfer of xenobiotics
size, polarity, lipid solubility, protein carrier
0%
causes fetal valproate syndrome
valporic acid
0%
3 ways endocrine disruptors work
mimic, blockers, triggers
0%
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