| Details of the mission | Spacecraft or astronaut name |
| First man-made satellite to orbit the earth | |
| First animal, a dog named Laika, sent into space aboard this Soviet craft | |
| First US satellite | |
| First satellite to orbit the moon | |
| First spacecraft to carry a human into space | |
| First human in space | |
| General name for the first manned US single-passenger spacecraft | |
| First US spacecraft to carry a human into space (suborbital) | |
| First American in space | |
| First manned US spacecraft to orbit the Earth | |
| First American to orbit the Earth | |
| First spacecraft to carry a woman into space | |
| First woman in space | |
| First spacecraft launch to feature a spacewalk | |
| First man to spacewalk | |
| General name for the first US twin-passenger spacecraft | |
| First US spacecraft to feature a spacewalk | |
| First American to spacewalk | |
| First spacecraft to soft-land on the Moon | |
| First US spacecraft to soft-land on the Moon | |
| First manned spacecraft to crash and cause a fatality | |
| First cosmonaut killled during spaceflight | |
| General name for the first US three-passenger spacecraft, designed to go to the Moon | |
| General name for the rocket that carried the first US three passenger spacecraft | |
| First US spacecraft to fail and cause fatalities | |
| First manned misson of a three-passenger spacecraft | |
| First manned mission to orbit the Moon | |