| Letter and Clue | Villain name | First Appearance |
| A - Later became the Spider-Slayer | |
| B - If he were a DC hero he'd be Blue | |
| C - A changeable sort of chap | |
| D - 4 metal arms 2, normal arms, 2 legs | |
| E - Shocking, just shocking | |
| F - Goes by the name 'Swarm' | |
| G - Pumpkin bomb anyone? | |
| H - He'll never be thirsty | |
| I - Not quite the Lizard (Obscure) | |
| J - Started the clone saga | |
| K - Big Game Hunter | |
| L - As a villain he's deadly, as a man he's armless. | |
| M - Feeds on plasma to stay alive | |
| | Letter and Clue | Villain name | First Appearance |
| N - Real name of answer to 'G' | |
| O - Real name of answer to 'D' | |
| P - A big cat or a sports brand | |
| Q - The first Mysterio | |
| R - A massive horny villain | |
| S - There's a sting in his tail | |
| T - Albino hard man | |
| U - The Most Recent Hobgoblin, Phil ... | |
| V - He gets quite attached | |
| W - The Kingpin | |
| X - I have no X. Just type X-men | |
| Y - I have no Y. Just type Yoda | |
| Z - I have no Z. Just type Zod | |
|