| Clue | Famous Holmes or Watson |
| Sleuth created by Arthur Conan Doyle | |
| Older brother of Doyle's detective | |
| Physician who assisted Doyle's famous detective | |
| Spiderman's girl friend | |
| One of the most widely cited U.S. Supreme Court justices, especially for 'clear and present danger' opinion in Schenck v. U.S. | |
| Guitar player, songwriter and singer of bluegrass, folk, country, blues and gospel music, winner of a Grammy Lifetime Achievement Award | |
| Actress who portrays Hermione Granger in the Harry Potter movies | |
| With Francis Crick and Maurice Wilkins, won the 1962 Nobel Prize for discovering the structure of DNA | |
| | Clue | Famous Holmes or Watson |
| Entrepreneur who built IBM into an industrial powerhouse | |
| Winner eight major golf championships, world's top ranked golfer from 1978 to 1982 | |
| Actress known for roles in Dawson's Creek and Batman Begins, married to Tom Cruise | |
| WBC Heavyweight Champion from 1978 to 1983 | |
| NFL Offensive Player of the Year in 2002, amassed 8172 career rushing yards | |
| Wide receiver for the Steelers and Jets, MVP of Super Bowl XLIII | |
| Singer-songwriter best known for 'Escape (The PiƱa Colada Song)' | |
| Psychologist who established the psychological school of behaviorism, conducted the controversial 'Little Albert' experiment | |
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