Drugs MVST IB - part 1

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Can you name the drugs from MVST IB - part 1?

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DescriptionDrug nameUse
Irreversible anticholinesterase - organophosphorus agent
Non-peptide angiotensin II antagonist - acts on AT1 receptors
Orally-acting hypoglycaemic agent - sulphonylurea
Double chain recombinant human tissue plasminogen activator
Causes development of new blood vessels
Used experimentally to inhibit dopamine beta-hydroxylase - also inhibits aldehyde dehyddrogenase
NSAID used to prevent thrombosis
Non-peptide inhibitor of glycoprotein IIb/IIIa receptor
Co-released with NA or ACh - acts on purinoceptors (P2 > P1)
Local anaesthetic - weak base - use-dependence and voltage-dependence
Potent, irreversible inhibitor of iNOS in activated macrophages
Acts on imidazoline receptors
Binds to SNAREs involved in membrane fusion, preventing ACh release
Inhibits platelet activation by inhibiting binding of ADP to its receptor on platelets
Inodilator used to treat canine dilated cardiomyopathy - calcium sensitiser
Potassium-sparing diuretic - blocks apical Na+ channels in late distal tubule
Lowers VLDL (and LDL) by stimulating lipoprotein lipase - may activate PPARs
Indirectly-acting sympathomimetic amine - weak inhibitor of MAO
Irreversible antagonist at nicotinic NMJ receptors (no effect on ganglionic receptors)
Selective antagonist for M1 muscarinic receptors
ACE inhibitor
Nitrovasodilator - produces NO - metabolised in liver to active drug
Converted to alpha-methylNA - released as false transmitter - more potent at alpha-2, less potent at alpha-1
Selective MAO-B inhibitor
Selective alpha-2 antagonist (slight effect on alpha-1)
COMT inhibitor
Naturally occurring anticoagulant produced by basophils/mast cells - exposes active site of antithrombin III
Regulates expression of multiple angiogenic genes
K channel opener
Non-specific endothelin receptor antagonist
Beta-1 antagonist used in heart failure
Cardiac glycoside - inhibits Na/K-ATPase
Non-selective, reversible MAO inhibitor
Loop diuretic - blocks Na/K/2Cl transport in thick ascending limb
Tyrosine kinase inhibitor
Partial agonist at alpha-adrenoceptors - 5-HT agonist
Selective non-depolarising neuromuscular blocker at NMJ - ester, broken down by spontaneous hydrolysis and plasma esterases
Direct acting vasodilator - metabolised to NO or cyanide
Irreversible anticholinesterase - activated by replacement of sulphur atom with oxygen, deoxified by plasma carboxylesterases
Use-dependent block of ganglionic transmission
Selective antagonist for M3 muscarinic receptor
Progestagen receptor antagonist
NOS inhibitor - not very selective for different forms
Quaternary local anaesthetic analogue - only effective if perfused inside cells
Blocks If current in SA node
Tricyclic antidepressant - blocks NET
Beta-1 agonist - weak beta-2 agonist
Competitively inhibits plasminogen activation - inhibits severe bleeding from excessive clot lysis
Mineralocorticoid receptor antagonist - potassium-sparing diuretic
Calcium channel blocker - phenylalkylamine - class IV antidysrhythmic
Blocks release of neurotransmitter via phospholipase A2 - localises to membrane by K channel binding moiety
Combined alpha- and beta-adrenoceptor antagonist
DescriptionDrug nameUse
Inhibits clotting by inhibiting synthesis of factors II, VII, IX, IX and regulatory proteins C, S, Z
ADP-ribosylates alpha-s - inhibits GTPase activity - sustained activation of adenylyl cyclase
Blocks release of NA evoked by APs (repeated low doses/aftermath of large dose) - indirect sympathomimetic actions (large doses)
Local anaesthetic - slow onset/offset - use dependence at low rates of stimulation - class IA antidysrhythmic
Non-selective alpha-adrenoceptor antagonist
Binds to plasminogen activator, increasing generation of plasmin
Immunosuppressant drug with antiproliferative effects
Depolarising blocker selective for NMJ nicotinic receptor - very short duration of action, broken down by BuChe - deficiency in enzyme activity can lead to prolonged action
Estrogen receptor agonist
Binds to neurexins, causing massive ACh release from nerve terminals
Phosphodiesterase III inhibitor - inodilator
Angiotensin II partial agonist
Experimental cardiac glycoside
Competitive antagonist for ganglionic nicotinic receptor - inactive at NMJ
K channel opener - also hirsutism effects
Tricyclic antidepressant - blocks NET
Blocks Na channels from exterior - no use-dependence
Inhibits DOPA decarboxylase in periphery
Glucocorticoid receptor antagonist
Blocks uptake of choline into neurons
Selective alpha-1 agonist (some action on beta-1)
Mild partial beta-1 agonist
ADP-ribosylates alpha-i - prevents activation of Gi in response to stimulation
Intracellular tetravalent polyamine - helps produce inward rectification of K+ channels
Non-selective phosphodiesterase inhibitor
Cholinergic agonist - not selective between nicotinic/muscarinic receptors
Inhibits liver triglyceride production and VLDL secretion - increases levels of tissue plasminogen activator
Thiazide diuretic - blocks Na/Cl transport in early distal tubule
Non-selective agonist for muscarinic receptors
Non-selective phosphodiesterase inhibitor
PPAR-gamma agonist
Illegal drug - blocks NET
Very potent alpha-2 agonist
Selective alpha-1 antagonist (slight effect on alpha-2)
Carbonic anhydrase inhibitor
Alpha-2 antagonist (some effect on alpha-1)
Depolarising blocker selective for ganglion nicotinic receptor
Mineralocorticoid receptor agonist
Phosphodiesterase III inhibitor - inodilator
Potassium-sparing diuretic - blocks apical Na+ channels in late distal tubule
K channel opener
Monoclonal antibody against glycoprotein IIb/IIIa receptor - prevents platelet aggregation - also binds to vitronectin receptor
Local anaesthetic (ester, weak base) - broken down by BuChE
Cholinergic agonist - +-isomer hydrolysed by AChE
Class III antidysrhythmic - prolongs AP and refractory period
Nitrovasodilator - produces NO
Reversible anticholinesterase - ionic interaction
Nitrovasodilator - produces NO - taken sublingually
Interferes with normal function of microtubule growth
Competitively inhibits plasminogen activation - inhibits severe bleeding from excessive clot lysis
Anion exchange resin - prevents reuptake of bile acids from intestine
Depolarising blocker at NMJ
DescriptionDrug nameUse
Non-selective beta-adrenoceptor antagonist
Calcium channel agonist - dihydropyridine
Cyclic heptapeptide inhibitor of glycoprotein IIb/IIIa receptor
Plasminogen + anisoylated streptokinase
Non-selective agonist for muscarnic receptors
Medium 'reversible' anticholinesterase - binds to esteratic site and carbamoylates ACh
Selective beta-1 antagonist (slight effect on beta-2)
Inhibits HMG-CoA reductase - also many pleiotropic effects
Binds very tightly to VMAT-2, preventing loading of catecholamines into vesicles
ACE inhibitor - prodrug, must be metabolised in liver
Uncompetitive inhibitor of phosphatase acting on IP1 --> inositol
Selective alpha-2 agonist
Beta-adrenoceptor agonist
Blocks transport of adenosine into cells - phosphodiesterase type V inhibitor
Reverse inhibition of AChE by organophosphorus agents
Competitive inhibitor of tyrosine hydroxylase
Calcium channel antagonist - dihydropyridine - affects L-type but not T-type channels
Osmotic diuretic - filtered at glomerulus, not reabsorbed
Irreversibly alkylates muscarinic receptor
Nicotinic receptor antagonist - relatively non-selective between NMJ and ganglion at clinical doses
Selective inhibitor of NOS in neurons
Inhibits intestinal absorption of cholesterol - circulates enterohepatically
Single chain recombinant human tissue plasminogen activator
Selective inhibitor of phosphodiesterase type V (selectively breaks down cGMP)
K channel opener - also NO donor
Selective non-depolarising neuromuscular blocking agent at NMJ - long action, not hydrolysed
Selective beta-2 antagonist (slight effect on beta-1)
alpha-1 antagonist most commonly used
Acts on imidazoline receptors
Arteriolar vasodilator - unknown mechanism
Local anaesthetic - uncharged
Beta-1 antagonist used in heart failure
Indirectly acting sympathomimetic amine - converted to octopamine by DBH - found in various foodstuffs
Blocks transporter carrying ACh into storage vesicles
Binds to synaptobrevin to prevent vesicle release from inhibitory interneuron synapses with motor neurons
Estrogen receptor antagonist
Class IC antidysrhythmic
Progestagen receptor agonist
Glucocorticoid receptor agonist
Orally-acting hypoglycaemic agent - sulphonylurea
Selective MAO-A inhibitor
Involved with providing new blood flow to ischaemic tissues
Slightly selective alpha-2 agonist (also alpha-1 actions) - omitting dose can lead to rebound hypertension
Competitive antagonist for ganglionic nicotinic receptors - inactive at NMJ
Irreversible alpha-adrenoceptor antagonist - blocks Uptake 2 (and Uptake 1 at 10x higher concs)
SSRI - blocks 5-HT transporter in Uptake 1
Muscarinic receptor antagonist - very long duration of action
Selective beta-2 agonist (slight effect on beta-1)
A1 receptor antagonist - non-selective phosphodiesterase inhibitor
Muscarinic receptor agonist
Calcium sensitiser - increases cardiac Ca2+ binding efficiency to troponin - inhibits phosphodiesterase III
Calcium channel blocker - benzothiazepine

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Created May 3, 2010ReportNominate
Tags:description, drug