| Description | Drug name | Use |
|---|
| Used experimentally to inhibit dopamine beta-hydroxylase - also inhibits aldehyde dehyddrogenase | |
| ADP-ribosylates alpha-i - prevents activation of Gi in response to stimulation | |
| Orally-acting hypoglycaemic agent - sulphonylurea | |
| Single chain recombinant human tissue plasminogen activator | |
| Direct acting vasodilator - metabolised to NO or cyanide | |
| Experimental cardiac glycoside | |
| Local anaesthetic (ester, weak base) - broken down by BuChE | |
| Nitrovasodilator - produces NO | |
| Quaternary local anaesthetic analogue - only effective if perfused inside cells | |
| Glucocorticoid receptor antagonist | |
| Blocks release of neurotransmitter via phospholipase A2 - localises to membrane by K channel binding moiety | |
| Selective beta-1 antagonist (slight effect on beta-2) | |
| Selective non-depolarising neuromuscular blocking agent at NMJ - long action, not hydrolysed | |
| Selective alpha-2 agonist | |
| Selective inhibitor of phosphodiesterase type V (selectively breaks down cGMP) | |
| Irreversible antagonist at nicotinic NMJ receptors (no effect on ganglionic receptors) | |
| Anion exchange resin - prevents reuptake of bile acids from intestine | |
| Plasminogen + anisoylated streptokinase | |
| Arteriolar vasodilator - unknown mechanism | |
| Non-peptide angiotensin II antagonist - acts on AT1 receptors | |
| Non-selective agonist for muscarnic receptors | |
| Converted to alpha-methylNA - released as false transmitter - more potent at alpha-2, less potent at alpha-1 | |
| Selective non-depolarising neuromuscular blocker at NMJ - ester, broken down by spontaneous hydrolysis and plasma esterases | |
| ACE inhibitor - prodrug, must be metabolised in liver | |
| Competitive inhibitor of tyrosine hydroxylase | |
| Nicotinic receptor antagonist - relatively non-selective between NMJ and ganglion at clinical doses | |
| Binds very tightly to VMAT-2, preventing loading of catecholamines into vesicles | |
| Monoclonal antibody against glycoprotein IIb/IIIa receptor - prevents platelet aggregation - also binds to vitronectin receptor | |
| Immunosuppressant drug with antiproliferative effects | |
| Calcium channel antagonist - dihydropyridine - affects L-type but not T-type channels | |
| Co-released with NA or ACh - acts on purinoceptors (P2 > P1) | |
| Inhibits HMG-CoA reductase - also many pleiotropic effects | |
| Selective MAO-A inhibitor | |
| Blocks If current in SA node | |
| Acts on imidazoline receptors | |
| Carbonic anhydrase inhibitor | |
| Irreversibly alkylates muscarinic receptor | |
| Depolarising blocker at NMJ | |
| Class IC antidysrhythmic | |
| Selective alpha-2 antagonist (slight effect on alpha-1) | |
| Blocks transporter carrying ACh into storage vesicles | |
| Regulates expression of multiple angiogenic genes | |
| Binds to neurexins, causing massive ACh release from nerve terminals | |
| Potassium-sparing diuretic - blocks apical Na+ channels in late distal tubule | |
| Irreversible alpha-adrenoceptor antagonist - blocks Uptake 2 (and Uptake 1 at 10x higher concs) | |
| Orally-acting hypoglycaemic agent - sulphonylurea | |
| Selective antagonist for M1 muscarinic receptors | |
| Selective antagonist for M3 muscarinic receptor | |
| Local anaesthetic - weak base - use-dependence and voltage-dependence | |
| Blocks uptake of choline into neurons | |
| Interferes with normal function of microtubule growth | |
| Uncompetitive inhibitor of phosphatase acting on IP1 --> inositol | |
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