Infectious Disease Block 6 - Fungus

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Can you name the Infectious Disease Block 6?

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QuestionAnswerAdditional information
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
candida strain resistant to azoles
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
Risk factor for yeast infection
diaper rash
HIV, Thailand, Red pigment
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
Strain of cryptococcus that hits immunecompromised
Ring worm
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Athletes foot
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Arizona/mexico border, Confussion/meningitis
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
Pseudo membrane in oropharynx - thrush.
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
Serology is great and should ALWAYS be followed
When in serum grows pseudohyphae. Retinal presentations
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
Tx for Zygomycetes
Ubiquitous with hyphae branching at acute angles
Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
Intracellular fungus, Spelunking, prisons, chicken coops
Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
prophylaxis for pneumocystis and toxoplasmosis
Diabetic mucormycosis
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
QuestionAnswerAdditional information
Dx stain for Cryto
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.
Immunecompromised w/ old dressings or IVs mucormycosis
Jock Rot 'well demarcated line'
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Fungal infection that runs along lymphatic vessel. Rose growers disease
Bone fungal infections
Apical lung fungal ball
Bone marrow recipients/leukemic pts. mucormycosis
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
Tx for cryptococcus meningitis (Abv.)
Parental drug addict mucormycosis
HIV Finger nail infection
Distal finger nail infection
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
Narrow base budding
Serology is terrible and is often false positive for histoplasmosis
Dose dependent Candida strain
Never use this for diagnosis of cryptococcus
Massive laryngeal mass causing obstruction - South americam agricultural worker
Bind to fungal heme iron in cytochrome P-450
right angle hyphae
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.
Fungal infection causing baldness
Strain of cryptococcus on the west coast and hits non-immuncompromised

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