Infectious Disease Block 6 - Fungus

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Can you name the Infectious Disease Block 6?

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Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
Fungal infection causing baldness
When in serum grows pseudohyphae. Retinal presentations
HIV Finger nail infection
Ring worm
Strain of cryptococcus on the west coast and hits non-immuncompromised
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Dx stain for Cryto
Strain of cryptococcus that hits immunecompromised
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
candida strain resistant to azoles
Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
Ubiquitous with hyphae branching at acute angles
HIV, Thailand, Red pigment
Tx for Zygomycetes
Bone marrow recipients/leukemic pts. mucormycosis
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.
Parental drug addict mucormycosis
Massive laryngeal mass causing obstruction - South americam agricultural worker
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
Bone fungal infections
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
Intracellular fungus, Spelunking, prisons, chicken coops
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions
Narrow base budding
Athletes foot
QuestionAnswerAdditional information
Diabetic mucormycosis
right angle hyphae
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
Serology is great and should ALWAYS be followed
Serology is terrible and is often false positive for histoplasmosis
Pseudo membrane in oropharynx - thrush.
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)
Bind to fungal heme iron in cytochrome P-450
Jock Rot 'well demarcated line'
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
Apical lung fungal ball
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
Immunecompromised w/ old dressings or IVs mucormycosis
Never use this for diagnosis of cryptococcus
diaper rash
Distal finger nail infection
Dose dependent Candida strain
Tx for cryptococcus meningitis (Abv.)
Risk factor for yeast infection
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
prophylaxis for pneumocystis and toxoplasmosis
Fungal infection that runs along lymphatic vessel. Rose growers disease
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Arizona/mexico border, Confussion/meningitis
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.

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