Infectious Disease Block 6 - Fungus

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When in serum grows pseudohyphae. Retinal presentations
diaper rash
prophylaxis for pneumocystis and toxoplasmosis
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
Tx for cryptococcus meningitis (Abv.)
Intracellular fungus, Spelunking, prisons, chicken coops
Pseudo membrane in oropharynx - thrush.
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
Dx stain for Cryto
right angle hyphae
Narrow base budding
Serology is terrible and is often false positive for histoplasmosis
Distal finger nail infection
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
Ubiquitous with hyphae branching at acute angles
Massive laryngeal mass causing obstruction - South americam agricultural worker
Arizona/mexico border, Confussion/meningitis
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.
Strain of cryptococcus on the west coast and hits non-immuncompromised
Parental drug addict mucormycosis
Jock Rot 'well demarcated line'
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
candida strain resistant to azoles
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
Tx for Zygomycetes
Immunecompromised w/ old dressings or IVs mucormycosis
QuestionAnswerAdditional information
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
Strain of cryptococcus that hits immunecompromised
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
Athletes foot
Never use this for diagnosis of cryptococcus
Serology is great and should ALWAYS be followed
Bind to fungal heme iron in cytochrome P-450
HIV Finger nail infection
Fungal infection that runs along lymphatic vessel. Rose growers disease
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
Bone marrow recipients/leukemic pts. mucormycosis
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Bone fungal infections
Apical lung fungal ball
Diabetic mucormycosis
Dose dependent Candida strain
Risk factor for yeast infection
Fungal infection causing baldness
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.
Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
Ring worm
HIV, Thailand, Red pigment
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)

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