Infectious Disease Block 6 - Fungus

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Can you name the Infectious Disease Block 6?

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QuestionAnswerAdditional information
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions
Apical lung fungal ball
Ubiquitous with hyphae branching at acute angles
right angle hyphae
Intracellular fungus, Spelunking, prisons, chicken coops
Diabetic mucormycosis
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
Bind to fungal heme iron in cytochrome P-450
Strain of cryptococcus on the west coast and hits non-immuncompromised
When in serum grows pseudohyphae. Retinal presentations
Arizona/mexico border, Confussion/meningitis
Dose dependent Candida strain
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Serology is great and should ALWAYS be followed
Dx stain for Cryto
Athletes foot
Ring worm
Parental drug addict mucormycosis
candida strain resistant to azoles
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Never use this for diagnosis of cryptococcus
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
Tx for cryptococcus meningitis (Abv.)
Jock Rot 'well demarcated line'
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)
HIV Finger nail infection
QuestionAnswerAdditional information
Fungal infection that runs along lymphatic vessel. Rose growers disease
Fungal infection causing baldness
Immunecompromised w/ old dressings or IVs mucormycosis
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
Bone fungal infections
Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.
Pseudo membrane in oropharynx - thrush.
prophylaxis for pneumocystis and toxoplasmosis
Tx for Zygomycetes
Massive laryngeal mass causing obstruction - South americam agricultural worker
Risk factor for yeast infection
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
HIV, Thailand, Red pigment
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Distal finger nail infection
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
Narrow base budding
Serology is terrible and is often false positive for histoplasmosis
Strain of cryptococcus that hits immunecompromised
Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
Bone marrow recipients/leukemic pts. mucormycosis
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
diaper rash
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.

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