Infectious Disease Block 6 - Fungus

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Can you name the Infectious Disease Block 6?

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Dx stain for Cryto
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Fungal infection that runs along lymphatic vessel. Rose growers disease
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
Narrow base budding
Serology is terrible and is often false positive for histoplasmosis
Tx for Zygomycetes
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
When in serum grows pseudohyphae. Retinal presentations
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
HIV Finger nail infection
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
Tx for cryptococcus meningitis (Abv.)
candida strain resistant to azoles
Immunecompromised w/ old dressings or IVs mucormycosis
Diabetic mucormycosis
Bone marrow recipients/leukemic pts. mucormycosis
Bone fungal infections
Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
Fungal infection causing baldness
Dose dependent Candida strain
Bind to fungal heme iron in cytochrome P-450
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)
QuestionAnswerAdditional information
Distal finger nail infection
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Ubiquitous with hyphae branching at acute angles
Massive laryngeal mass causing obstruction - South americam agricultural worker
HIV, Thailand, Red pigment
Ring worm
prophylaxis for pneumocystis and toxoplasmosis
Athletes foot
Serology is great and should ALWAYS be followed
Strain of cryptococcus on the west coast and hits non-immuncompromised
Apical lung fungal ball
Arizona/mexico border, Confussion/meningitis
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
right angle hyphae
Jock Rot 'well demarcated line'
Strain of cryptococcus that hits immunecompromised
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
Never use this for diagnosis of cryptococcus
Pseudo membrane in oropharynx - thrush.
Parental drug addict mucormycosis
Intracellular fungus, Spelunking, prisons, chicken coops
Risk factor for yeast infection
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
diaper rash
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.

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