Infectious Disease Block 6 - Fungus

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Side effects are: Shake and Bake (fever chills, headache, nausea, vomiting) mediated through release of prostaglandin E. Renal toxicity is closely watched.
Athletes foot
Dose dependent Candida strain
Jock Rot 'well demarcated line'
Narrow base budding
Strain of cryptococcus that hits immunecompromised
Tx for Zygomycetes
Never use this for diagnosis of cryptococcus
DNA synthesis inhibitor. Goes to the CNS. Can Cause hemorrhagic colitis and pancytopenia
When in serum grows pseudohyphae. Retinal presentations
Intracellular fungus, Spelunking, prisons, chicken coops
Diabetic mucormycosis
Drug that is concentrated in the skin. Side effect is a loss of taste. Effective against dimorphic fungi in nails and skin
Pseudo membrane in oropharynx - thrush.
Rapid O2 desaturation upon exertion. Life threatening pneumonia in AIDS. Ubiquitous
Anti-fungal with 3 fluorides. Tx for aspergillus. S/E - Bone pain, alteration in electroretinogram, increased alkaline phos, periostitis, Visual scatoma. Multiple drug interactions
right angle hyphae
HIV, Thailand, Red pigment
MCC of fungal meningitis in AIDS pts. Pidgeon poop.
Need to suppliment with potassium, magnesium and EPO because of its renal toxicity.
Dx stain for Cryto
Tx for cryptococcus meningitis (Abv.)
Parental drug addict mucormycosis
candida strain resistant to azoles
Massive laryngeal mass causing obstruction - South americam agricultural worker
Fungal infection causing baldness
Immunecompromised w/ old dressings or IVs mucormycosis
Broad base budding, In soil. Great lakes. Beavers. Hits Normal immune systems. Fisherman, campers, hunters
QuestionAnswerAdditional information
Ring worm
Serology is great and should ALWAYS be followed
Drug addict, diabetic w/ ketoacidosis, Bone transplant recipient, Renal Failure. Black necrosis of the ororpharynx. Rapid presentation
HIV Finger nail infection
Treats ring worm and nail infections. Inhibits nucleic acid synthesis
Distal finger nail infection
Apical lung fungal ball
Strain of cryptococcus on the west coast and hits non-immuncompromised
Tx for histoplasmosis, spirotrichosis, and blastomyces. Taken with food/coca cola. Side effects: Adrenal excess (edema, hypertension, hypokalemia) nausea, vomiting. Long term - per
Arizona/mexico border, Confussion/meningitis
Bind to fungal heme iron in cytochrome P-450
Drug with multiple double bonds and intercalates into fungal plasma membranes creating lytic pores
Risk factor for yeast infection
Bone marrow recipients/leukemic pts. mucormycosis
erythema nodosum, hilar adenopathy. Apical cavitary disease. Dark skin and pregnancy are risk factors. Meningitis = Tx for life
Skinny white male with COPD gets this fungal infection. pneumoia pericarditis, adrenal disease, adenocarcinoma like bowel lesions
Antifungal to treat fungal UTI's and has CSF penetration. Great pharmacokinetics.Treats coccidioides.
Low Alkaline phosphatase, LDH less than 300, Leukocytopenia. Diagnosed via urine serology
Ubiquitous with hyphae branching at acute angles
Fungal infection that runs along lymphatic vessel. Rose growers disease
Anti-fungal with Side effects of adrenal Insufficiency and hepatic necrosis. Needs gastric acid for absorption
Serology is terrible and is often false positive for histoplasmosis
Bone fungal infections
Antifungal drug whose mechanism is similar to that of penicillin to bacteria. Tx for candida and aspergillus.
Verrucous/warty skin lesions in cooler areas (tip of nose, fingers)
prophylaxis for pneumocystis and toxoplasmosis
Halo sign, wedge shaped pulmonary emboli infarct, immune compromised
diaper rash

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